New chemical compound stops common cold in its tracks!

on . Posted in Articles of Interest

Is this a cure for the common cold?

LONDON, England (PNN) - May 14, 2018 - It’s a conundrum that has stumped scientists for centuries, but now researchers say they have taken a tantalizing step forward in the quest to tackle the common cold.

The scourge of workplace, home and school playground, the common cold is predominantly caused by the rhinovirus. But attempts to thwart the pathogen by vaccination or antiviral drugs face a number of difficulties; not least because the virus comes in many forms and can mutate rapidly, leading to drug resistance.

But now scientists say they have discovered a way to incapacitate the virus that could one day help those with conditions such as asthma and cystic fibrosis, for whom a cold is not merely a nuisance but a serious health risk.

The trick, the authors say, is to develop drugs that interact with one of the enzymes within our cells - an approach that makes it harder for the virus to become drug-resistant.

“Viruses hijack the host to make more copies of themselves. This enzyme is one of the host enzymes that the virus hijacks,” said Roberto Solari, visiting professor at the National Heart and Lung Institute, Imperial College London, and a co-author of the study.

Writing in the journal Nature Chemistry, a team of researchers based around the Fascist United Kingdom report how they looked at molecules that interact with a human enzyme that attaches a type of fatty acid molecule on to proteins. While two of these molecules on their own had little effect on the enzyme, the team found that when they were chemically stitched together they became remarkably potent in preventing the enzyme from working as normal.

Solari said that is important, since the virus uses the enzyme to assemble the protein coat that surrounds the genetic material of the virus.

“What we found is if we block the addition of this fat, the coat doesn’t assemble so the virus doesn’t package its genes into its coat,” he said. “The virus still makes its own genes, it makes the coat, but the coat can’t assemble so the virus can’t replicate - you actually don’t make infectious particles.”

The team says the molecule appears to completely prevent the virus from replicating, whether it is added one hour before, one hour after, or at the same time as the cells are infected, and that it remains effective up to three hours after infection. The approach was also found to prevent the replication of other viruses in the same family as rhinovirus, including polio and foot-and-mouth disease.

But Solari said a cure for the common cold is a long way off. The drug will need to undergo further developments and optimization before it can be used as a medication, while tests have so far only been carried out on human cells in a dish.

“We haven’t done any animal studies, and we obviously haven’t done any studies in humans, so I can’t tell you formally what the animal toxicity of this compound is,” said Solari, adding that it is also unclear whether the approach would work by the time symptoms of a cold appear - typically a few days after infection.

Even if the latest discovery does eventually lead to a way to treat colds, its use is likely to be limited to those with respiratory conditions such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, for whom catching a cold can be dangerous.

“Rhinovirus - the common cold virus - in healthy people is pretty trivial. You have the runny nose, you have a bit of a temperature, you don’t feel well for two or three days, but you get over it,” said Solari.

Eulogies

Eulogy for an Angel
1992-Dec. 20, 2005

My Father
1918-2010

brents dad

Dr. Stan Dale
1929-2007

stan dale

A. Solzhenitsyn
1918-2008

solzhenitsyn

Patrick McGoohan
1928-2009

mcgoohan

Joseph A. Stack
1956-2010

Bill Walsh
1931-2007

Walter Cronkite
1916-2009

Eustace Mullins
1923-2010

Paul Harvey
1918-2009

Don Harkins
1963-2009

Joan Veon
1949-2010

David Nolan
1943-2010

Derry Brownfield
1932-2011

Leroy Schweitzer
1938-2011

Vaclav Havel
1936-2011

Andrew Breitbart
1969-2012

Dick Clark
1929-2012

Bob Chapman
1935-2012

Ray Bradbury
1920-2012

Tommy Cryer
1949-2012

Andy Griffith
1926-2012

Phyllis Diller
1917-2012

Larry Dever
1926-2012

Brian J. Chapman
1975-2012

Annette Funnicello
1942-2012

Margaret Thatcher
1925-2012

Richie Havens
1941-2013

Jack McLamb
1944-2014

James Traficant
1941-2014

jim traficant

Dr. Stan Monteith
1929-2014

stan montieth

Leonard Nimoy
1931-2015

Leonard Nimoy

Stan Solomon
1944-2015

Stan Solomon

B. B. King
1926-2015

BB King

Irwin Schiff
1928-2015

Irwin Schiff

DAVID BOWIE
1947-2016

David Bowie

Muhammad Ali
1942-2016

Muhammed Ali

GENE WILDER
1933-2016

gene wilder

phyllis schlafly
1924-2016

phylis schafly

John Glenn
1921-2016

John Glenn

Charles Weisman
1954-2016

Charles Weisman

Carrie Fisher
1956-2016

Carrie Fisher

Debbie Reynolds
1932-2016

Debbie Reynolds

Roger Moore
1917-2017

Roger Moore

Adam West
1928-2017

Adam West

JERRY LEWIS
1926-2017

jerry lewis

HUGH HEFNER
1926-2017

Hugh Hefner

PROF. STEPHEN HAWKING
1942-2018

Hugh Hefner 

ART BELL
1945-2018

Art Bell

DWIGHT CLARK
1947-2018

dwight clark